PCFFGRA4 dXP'gB:   8ABLab LaserJetS 4dXXA4terBJDM 0Rt,T`Op,T`OpRt,TT`Op,TT,TT`OpXX'  d Rt Rt@ , Rt   Canon MP600R Printer ߁ 4d A4/nBArial  $"BSymbol  'BWingdings  $@}.~@9 *Transform of Copy of 0701903DB003_L929_BI ::?6;<=&=> ? ?@Transformed dataF`=3G3G3G3GZ[P=3G>3G?3GZ@9@9 #Shared params 0701903DB003_L929_BI ::;<=&AB3C?@ Equation?@Table of results?@CurveFd,_b@}@?}@}@3G3G3G3GG,'CH3G?3G?3G?3G?3Gy"s ??IxY=BOTTOM+(TOP-BOTTOM)/(1+10^(SLOPE*(EC50-X))) Y=BOTTOM+(TOP-BOTTOM)/(1+10^(SLOPE*(EC50+LOGRP-X))) Y=BOTTOM P2 parallel 4PLs with RPQ1?$@??$@@RSBOTTOMTOPSLOPEEC50LOGRPT( G?`-??|bX.6I`IPHQHX.6*IH`IPHQHX.608H@V AW(k ?[_?[nn??T"Ism?X(Ʒ@y?$|t?R}xgz? ?->?Y2$???`?V@V BW(k ?[_?[nn??T"Ism?X(Ʒ@y?$|t?R}xgz? ?->?Y2 ?@???V@V CW(k ?[_?[nn??T"Ism?X(Ʒ@y?$|t?R}xgz? ?->?Y2 G?`-??V@G@9@9 1model 2Transform of Copy of 0701903DB003_L929_BI ::?9;<=&PQR?@Transformed dataF`=3G3G3G3GZ[P=3G>3G?3GZ@9@9 Two EC50s 0701903DB003_L929_BI ::;<=&TU3V?@ Equation?@Table of results?@CurveFd,_b@}@?}@}@3G3G3G3GG,'VH3G?3G?3G?3G?3Gy"s ??IsY=BOTTOM+(TOP-BOTTOM)/(1+10^(SLOPE*(EC50-X))) Y=BOTTOM+(TOP-BOTTOM)/(1+10^(SLOPE*(EC502-X))) Y=BOTTOM P2 parallel 4PLs with two EC50sQ/?$@??$@@RSBOTTOMTOPSLOPEEC50EC502T( G?`-??|^X.6I`IPHQHX.6(I`IPHQHX.6.8H@V TW(wh2?7_?9&krn?j?X(W 4y?|t?\z?\1X,?Y2$???`?V@V UW(wh2?7_?9&krn??|INaN?X(W 4y?|t?\z?Nw#?Y2 ?@???V@V VW(wh2?7_?9&krn?X(W 4y?|t?\z?Y2 G?`-??V@G@9@ Copy of 0701903DB003_L929_BI : 0 =nn$(h  (  ( <@v JJ@ JJ@ JJ@ (=@tJ@tJ@t (>@tJ@tJ@t (?@tP@t. @t<<e  ng/mL CzCB zB'A.zA.@5z@<?<H><o:@<=e=<  IMx0753n.-=?.@?.v>?.#9?.m;?.6?.j4?.}?5?.C+?.D,?./?.+'?.Nb?.?.?.;>.(>.>.O>.>.t>.`P>.^I>.L>.u>.Nb>.'1>@<>e=<  IMx0757 (control)n.6?.=?.B`E?.Nb0?.X9?.A@?.V.?.1?.SC?.C+?.1,?.X94?.S#?.ˡ%?.V.?.C ?. ?.X?.V>.>.)\>./]>.F>.D>.u>.z>.)\>@<?e=< ! zero dose!.sh>.Nb>.q= >@@ ;Transform of Copy of 0701903DB003_L929_BI:Transformed data  0 =nn$(h $n$n@@s JJ@ JJ@ JJ@ (A@s'@s'@s (B@s'@s'@s (C@s' @s' @s<@f @ ng/mL@<Af=@ IMx0753@<Bf=@ IMx0757 (control)@<Cf=@ zero dose@@ 4Shared params 0701903DB003_L929_BI:Table of results  0 $(h $$E" J@ F@ G@ H@ N@<E f E##  #ImppIQ`0I<IJ IC0IJ IJ` IQ0I<IJ0 ICIJ` IIQ 0I<0 IJ ICP IJ Im pI8I5H(ICIQ0IQP0I<IJ IC IJ I ,HH I I I I2 parallel 4PLs with RPBest-fit values BOTTOM TOP SLOPE EC50 LOGRPStd. Error BOTTOM TOP SLOPE EC50 LOGRP95% Confidence Intervals BOTTOM TOP SLOPE EC50 LOGRPGoodness of Fit Degrees of Freedom R Absolute Sum of Squares Sy.xConstraints BOTTOM TOP SLOPE EC50 LOGRPData Number of X values Number of Y replicates Total number of values Number of missing values@<F f E## IMx0753#.H.H'H. HJp IB<I<I5 H5HJ IBtHItIf`ItIJp ICC. H<p ICtI_ PIm pIf `IJ IcC8H rG9H tG0.14070.73041.5270.9052(not used)0.0061300.0050020.068270.01657(not used)0.1284 to 0.15310.7204 to 0.74051.390 to 1.6640.8719 to 0.9385(not used)0.99650.004755BOTTOM is sharedTOP is sharedSLOPE is sharedEC50 is shared(not used)113276@<G f E## IMx0757 (control)#.H.H'H. H5HA<I<`I5H5H5HBtItIf0`ItIICC.H5@H!CtI_ PIm pIf `Im pIjC:H vG@;H wG0.14070.73041.5270.90520.041850.0061300.0050020.068270.016570.020200.1284 to 0.15310.7204 to 0.74051.390 to 1.6640.8719 to 0.93850.001271 to 0.082430.98930.01390BOTTOM is sharedTOP is sharedSLOPE is sharedEC50 is sharedLOGRP is shared113276@<H f E## zero dose#.HJ` IJ IJ IJ@ I8B<IJ` IJ IJ IJ@ IBtIJ IJ IJ  IJ ICC5HQ 0I(Ct@IJ IJ IJ IJ` I`C8H qG qG9H0.1407(not used)(not used)(not used)(not used)0.006130(not used)(not used)(not used)(not used)0.1284 to 0.1531(not used)(not used)(not used)(not used)-0.20723.4606e-005BOTTOM is shared(not used)(not used)(not used)(not used)113330@<Ne E Global (shared)&.H.H'H. H5H<I<`I5H5H5HtItIf0`ItII%H.H5H5`H0.14070.73041.5270.90520.041850.0061300.0050020.068270.016570.020200.1284 to 0.15310.7204 to 0.74051.390 to 1.6640.8719 to 0.93850.001271 to 0.08243520.99390.018690.01896@@ )Shared params 0701903DB003_L929_BI:Curve  0 nnJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ$J*h JJDr JJ@ I@s J@s K@s<D f D ng/mL@#<@<I f( D IMx0753@<J f( D IMx0757 (control)@<K f( D zero dose@@ $model 2Copy of 0701903DB003_L929_BI : 0 =nn$(h  (  ( O@v JJ@ JJ@ JJ@ (P@tJ@tJ@t (Q@tJ@tJ@t (R@tP@t. @t<Oe  ng/mL CzCB zB'A.zA.@5z@<?<H><o:@<Pe=O  IMx0753n.-=?.@?.v>?.#9?.m;?.6?.j4?.}?5?.C+?.D,?./?.+'?.Nb?.?.?.;>.(>.>.O>.>.t>.`P>.^I>.L>.u>.Nb>.'1>@<Qe=O  IMx0757 (control)n.6?.=?.B`E?.Nb0?.X9?.A@?.V.?.1?.SC?.C+?.1,?.X94?.S#?.ˡ%?.V.?.C ?. ?.X?.V>.>.)\>./]>.F>.D>.u>.z>.)\>@<Re=O ! zero dose!.sh>.Nb>.q= >@@ Bmodel 2Transform of Copy of 0701903DB003_L929_BI:Transformed data  0 =nn$(h $n$nS@s JJ@ JJ@ JJ@ (T@s'@s'@s (U@s'@s'@s (V@s' @s' @s<Sf S ng/mL@<Tf=S IMx0753@<Uf=S IMx0757 (control)@<Vf=S zero dose@@ 0Two EC50s 0701903DB003_L929_BI:Table of results  0 tttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttt$t(h $$X tJ@ Y@ Z@ [@ a@<Xf X!!  !ImpIQ0I<IJ ICIJ0 IJ IQp0I< IJ IC@IJ IIQ 0I< IJ IC IJP Im pIpI5 H`ICIQ0IQ0I<pIJ I +H I Ix IP I2 parallel 4PLs with two EC50sBest-fit values BOTTOM TOP SLOPE EC50 EC502Std. Error BOTTOM TOP SLOPE EC50 EC50295% Confidence Intervals BOTTOM TOP SLOPE EC50 EC502Goodness of Fit Degrees of Freedom R Absolute Sum of Squares Sy.xConstraints BOTTOM TOP SLOPEData Number of X values Number of Y replicates Total number of values Number of missing values@<Y f X!! IMx0753!.H.H'H. HJp IB<I<I5 H<IJ IBtPItIf`ItIJ ICC.@H< I CtI_ PIm pILC3H gG3H hG0.14070.73041.5270.9052(not used)0.0061290.0050020.068280.008356(not used)0.1284 to 0.15310.7204 to 0.74051.390 to 1.6640.8884 to 0.9220(not used)0.99650.004755BOTTOM is sharedTOP is sharedSLOPE is shared113276@<Z f X!! IMx0757 (control)!.H.H'HJ I.`HB<I<I5 HJ I5@HBtHItIf`IJp ItICC. H5HCtI_ PIm pIJC2H fG@3H gG0.14070.73041.527(not used)0.94710.0061290.0050020.06828(not used)0.015480.1284 to 0.15310.7204 to 0.74051.390 to 1.664(not used)0.9160 to 0.97820.98930.01390BOTTOM is sharedTOP is sharedSLOPE is shared113276@<[ f  X!! zero dose!.HJ` IJ IJ IJ@ I8B<IJ` IJ IJ IJ@ IBtIJ IJ IJ  IJ ICC5HQ 0I(Ct@IJ IJ ILC3H gG gG4H0.1407(not used)(not used)(not used)(not used)0.006129(not used)(not used)(not used)(not used)0.1284 to 0.1531(not used)(not used)(not used)(not used)-0.20723.4607e-005BOTTOM is shared(not used)(not used)113330@<ae X Global (shared)&.H.H'H<I<I5 Ht@ItIf`IH. H5 H5 Hpl0.14070.73041.5270.0061290.0050020.068280.1284 to 0.15310.7204 to 0.74051.390 to 1.664520.99390.018690.01896@@ %Two EC50s 0701903DB003_L929_BI:Curve  0 nnJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ$J*h JJWr JJ@ \@s ]@s ^@s<Wf W ng/mL@#<@<\ f( W IMx0753@<] f( W IMx0757 (control)@<^ f( W zero dose@@AB" PCDEA@AB" PCDEA@AB" PCDEA@A B" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@AB" PCDEA@A!B" PCDEA@A"B" PCDEA@A$B" PCDEA@A&B" PCDEA@A(B" PCDEA@A*B" PCDEA@A+B" PCDEA@A-B" PCDEA@A.B" PCDEA@A0B" PCDEA@A2B" PCDEA@A4B" PCDEA@A6B"4( C 4 DE X=Log(X) A@A7B" PCDEA@A9B"4( C 4 DE X=Log(X) A@A:B" PCDEA@ 0Transform of Copy of 0701903DB003_L929_BI graph :0 x2x d JABCI J K < 33 ݫ@ @ Z[\<<,?`????]^_<Y@Y@@`ab%zZ llv? 0l? JJJJw& zerolerol%@%z[@hhb?TZ 0l?JJJJw@h%@%z\Y@Z 0l$@JJJJwY@%@%z]??:mgE? 0l???JJJJw?:m%@%z^Y@Z 0l$@JJJJwY@%@%z_Y@Z 0l$@JJJJwY@%@%z`Y@UUUUUU? 0l$@JJJJwY@UU%@%zaY@Z 0l$@JJJJwY@%@%zbY@Z 0l$@JJJJwY@%@ " # !  k t P !x @   % `   x 0(AV}@$?? xxd )(@01Ix @    `  x 0(BV}@ ?@? xxd )(@01)x @  HZ6l6wTN0(C4 G?`-? xxd )(@0Z?1Z?x @   |  X h p 0(IC3tp@@pI?%V? xxd )(@0|1Cx @   |  X i p 0(JB3tp@??T? xxd )(@0|1Bx @  JZ6n6nVN0(K=?? xxd )(@0Z=1Z=x @   4  V f 0"!1/0+:,:Transform of Copy of 0701903DB003_L929_BI:Transformed data-. dkd+@x @ thP0# *Z"x @  k .  0# *]"x @ f <: \  2"!1 /0+,Y1Title- . dkd+@x @   0  (  "!/0A+,IMx0753- .kmKn+@x @  a ^K 0 :' ( " "!/0B+,IMx0757 (control)- .kmKn+@x @   0   ('  "!/0C+ , zero dose- .kmKn+@x @  t P 0# *["x @  4> V`j 0"!1/0+,ng/mL- . dkd+@x @ V~ Zz 6   0"!1/:0F+,YTitle- . dkd+@x @@T*Black and WhiteP@@ 7model 2Transform of Copy of 0701903DB003_L929_BI graph : 0 x2x d JTUV\ ] ^  < 33 ݫ@ @ cde<<,?`???? fgh<Y@Y@@ ijk%zc llv? 0l? w& zerolerol%@%zd@hhb?TZ 0l?w@h%@%zeY@Z 0l$@wY@%@%zf??:mgE? 0l???w?:m%@%zgY@Z 0l$@wY@%@%zhY@Z 0l$@wY@%@%ziY@UUUUUU? 0l$@wY@UU%@%zjY@Z 0l$@wY@%@%zkY@Z 0l$@wY@%@ " # !  k t P !x @   % `   x 0(TV}@$?? xxdA )(@01Ix @    `  x 0(UV}@ ?@? xxdA )(@01)x @  HZ6l6wTN0(V4 G?`-? xxdA )(@0Z?1Z?x @   |  X h p 0( \C3tp@ qI?%V? xxdA )(@0|1Cx @   |  X i p 0( ]B3tp@??T? xxdA )(@0|1Bx @  JZ6n6nVN0( ^=@?@? xxdA )(@0Z=1Z=x @ 8  \ f ~ D 0"!1/0+A,Amodel 2Transform of Copy of 0701903DB003_L929_BI:Transformed data-. dkd+@x @ thP0# *c"x @  k .  0# *f"x @ f <: \  2"!1 /0+ ,Y1Title- . dkd+@x @   0  (  "!/0A+ ,IMx0753- .kmKn+@x @  a ^K 0 :' ( " "!/0B+ ,IMx0757 (control)- .kmKn+@x @   0   ('  "!/0C+  , zero dose- .kmKn+@x @  t P 0# *d"x @  4> V`j 0"!1/0+,ng/mL- . dkd+@x @ V~ Zz 6   0"!1/:0F+ ,YTitle- . dkd+@x @@T*Black and WhiteP@@8 Project info 1 :mnExperiment Dateo Jan-9-2007nExperiment IDon Notebook IDonProjecton Experimenteron Protocolono8@@@